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Clinical Trial Summary

The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.


Clinical Trial Description

In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, amino acid profile (e.g., L-arginine), fatty acid profile, neuropsychologic parameters (e.g., appetite) and satiety-associated hormones (e.g., PYY) are assessed. Each intervention arm will be separated by a washout period of 14 days. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05208346
Study type Interventional
Source University of Bonn
Contact
Status Active, not recruiting
Phase N/A
Start date March 9, 2022
Completion date October 30, 2022

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