Cardiovascular Diseases Clinical Trial
Official title:
Using Exercise Echocardiography to Investigate the Effects of Different Exercise Trainings on Left Ventricular Mechanics in Patients With Coronary Artery Disease: a Speckle-tracking Echocardiography
Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. The aim of this study was to compare the LV function measured by 3 min low dose exercise stress echocardiography (ESE) combined 2D speckle tracking echocardiography (STE) in patients with CAD underwent PCI, and to identify factors affecting the change of LV function. Patients with CAD who underwent acute PCI were enrolled.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | July 31, 2022 |
Est. primary completion date | July 31, 2022 |
Accepts healthy volunteers | |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - acute myocardial infarction diagnosed by a physician - undergoing percutaneous coronary intervention - Exercise testing and stress echocardiography are performed with the approval of the physician. Exclusion Criteria: - Severe cardiac valve disease - Left bundle branch block - Uncontrolled diabetes or hypertension - Orthopedics or other conditions that hinder from exercise - Uncontrolled sinus tachycardia (greater than 120 beats per minute) |
Country | Name | City | State |
---|---|---|---|
Taiwan | Asia University Hospital | Wufeng | Taichung |
Lead Sponsor | Collaborator |
---|---|
China Medical University Hospital |
Taiwan,
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Huang YC, Tsai HH, Fu TC, Hsu CC, Wang JS. High-Intensity Interval Training Improves Left Ventricular Contractile Function. Med Sci Sports Exerc. 2019 Jul;51(7):1420-1428. doi: 10.1249/MSS.0000000000001931. — View Citation
Li H, Liu C, Zhang G, Wang C, Sun P, Du G, Tian J. The early alteration of left ventricular strain and dys-synchrony index in breast cancer patients undergoing anthracycline therapy using layer-specific strain analysis. Echocardiography. 2019 Sep;36(9):1675-1681. doi: 10.1111/echo.14460. Epub 2019 Aug 27. — View Citation
Sikora-Frac M, Zaborska B, Maciejewski P, Budaj A, Bednarz B. Improvement of left ventricular function after percutaneous coronary intervention in patients with stable coronary artery disease and preserved ejection fraction: Impact of diabetes mellitus. Cardiol J. 2019 Jul 1. doi: 10.5603/CJ.a2019.0066. [Epub ahead of print] — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The alterations of LV mechanics responses to a 3-min low dose exercise stress echocardiography following time. | The STE was performed at rest, during exercise and recovery to compare the changes of LV machines following discharge. The standardized exercise test was conducted by 50-W semirecumbent cycling (Cardiac Stress Table w/Angio) for 3 min. Stress echocardiograph images were acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR. | detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge. | |
Secondary | Cardiopulmonary fitness | The graded exercise test (GXT) was performed with a cycle ergometer at the day 30 and 180 after discharge. The GXT comprised of unloaded pedaling for 2 min followed by a continuous increase in work rate (20-30 W) every 3 min until exhaustion (i.e., V? O2max). Minute ventilation (V? E), V? O2, and CO2 production (V? CO2) were measured breath-by-breath using a computer-based system (MasterScreen CPX; Cardinal Health Germany). | detected at the day 30, 60, and 180 after discharge. | |
Secondary | The brain-type natriuretic peptide (BNP) levels | BNP levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The high-sensitivity CRP (hsCRP) levels | hsCRP levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The creatine kinase (CK) levels | The CK levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The creatine kinase-MB (CK-MB) levels | The CK-MB levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The troponin I levels | The troponin I levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The left ventricle wall and cavity dimensions | M-mode images were used to determine the LV wall and cavity dimensions at end-systole and end-diastole from a parasternal long axis view. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The left ventricle mass | Measurements of LVmass and the short fraction index were automatically derived using standard equations as followed: LVmass(gm) = 0.77 X 10^-3X [(IVS + LVIDd +PW)^3 - (LVIDd)^3 + 2.4] | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The left ventricle ejection fraction | LV ejection fraction (LVEF) was determined using the modified Simpson's method from the apical four-chamber views. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | |
Secondary | The left ventricle diastolic functions | Analysis of Doppler pulsed wave was performed to determine diastolic transmitral blood flow velocities for peak early (E) and late (A) fillings and was also detected the diastolic mitral annular tissue velocities for peak early (E') and late (A') fillings. | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. |
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