Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease

Cardiovascular Diseases Clinical Trial

— PL-PARTICLES  

Official title:

Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04541498
• Other study ID #: UMB-KKI-103
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: January 1, 2022

Study information

• Verified date: September 2021
• Source: Medical University of Bialystok
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Despite the fact that the topic of air pollution has been in focus of researchers for many years, there are no big studies that take up the matter of its influence on acute coronary, cerebral syndromes and CVD mortality in Europe. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution on cardiovascular diseases and CVD mortality in Poland.

Description:

Air quality and its impact on health was put in the spotlight since the infamous Great Smog of London. Since then, it became clear that adverse effects are serious and can no longer be ignored. According to the World Health Organization (WHO) estimations, in last year ambient air pollution caused 4,200,000 deaths worldwide. These statistics included a total of 29,165 deaths that were attributed to air pollution in Poland.

The vast of studies are conducted in highly polluted areas, in which patients are exposed to extreme concentrations like China oraz Indie. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution and cardiovascular diseases in Poland.

Data on morbidity and mortality were collected from the National Statistical Office in Poland. The data of air pollutions and gases were obtained from Voivodeship Inspectorate for Environmental Protection. The daily meteorological data were obtained from the Institute of Meteorology and Water Manageme

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150000
• Est. completion date: January 1, 2022
• Est. primary completion date: August 1, 2021
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion criteria:

• residents from analysed area.

Exclusion criteria

• none

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Cardiovascular Diseases
• Cardiovascular Risk Factor
• Chronic Coronary Insufficiency
• Particulate Matter Inhalation Injury
• Pollution; Exposure

Intervention

Other:
• Impact of air pollution and climate changes
To assess the short- and long- term impact of air pollution and climate changes

Locations

Country	Name	City	State
Poland	Department of Invasive Cardiology Medical University of Bialystok 24A M. Sklodowskiej-Curie St.	Bialystok

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Bialystok

Country where clinical trial is conducted

Poland, 

References & Publications (4)

Kuzma L, Pogorzelski S, Struniawski K, Bachórzewska-Gajewska H, Dobrzycki S. Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry). Int J Hyg Environ Healt — View Citation

Kuzma L, Pogorzelski S, Struniawski K, Dobrzycki S, Bachórzewska-Gajewska H. Effect of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients. Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15 — View Citation

Kuzma L, Struniawski K, Pogorzelski S, Bachórzewska-Gajewska H, Dobrzycki S. Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Foll — View Citation

Kuzma L, Wanha W, Kralisz P, Kazmierski M, Bachórzewska-Gajewska H, Wojakowski W, Dobrzycki S. Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,00 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of acute coronary syndromes	Number of acute coronary syndromes related with impact of air pollution	Through study completion, an average of 1 year
Primary	Incidence of cardiovascular mortality	Number of cardiovascular deaths related with impact of air pollution	Through study completion, an average of 1 year
Primary	Incidence of acute cerebral syndromes	Number of acute cerebral syndromes related with impact of air pollution	Through study completion, an average of 1 year