Cardiovascular Diseases Clinical Trial
Official title:
An Observational, Cross-sectional Study Into the Future Cardiovascular Disease (CVD) Risk of Phenylketonuria (PKU) Patients on a Low Phenylalanine Treatment Diet (LPD).
This study will assess the cardiovascular disease (CVD) risk in Phenylketonuria (PKU)
patients on a low-phenylalanine diet (LPD).
Ultrasound tests, diet information and routine blood samples will be collected once per
patient at their next outpatient appointment.
32 adults with PKU will be studied and compared to reference data for healthy people. The
results will show if the PKU CVD risk differs from healthy people, and if CVD risk varies
within people with PKU.
Cardiovascular disease (CVD) is the largest cause of deaths worldwide each year. Many factors
affect CVD including diet, genetics, exercise and smoking. It is unclear if Phenylketonuria
(PKU) and the low-phenylalanine diet (LPD) affect CVD risk.
CVD risk can be predicted by measuring the thickness of the artery wall in the neck which
supplies blood to the head. Thickness is measured using a non-invasive, safe ultrasound test
(similar to pregnancy jelly scans). A wall thicker than normal indicates an increased CVD
risk. A wall thinner than normal indicates a lower CVD risk.
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