Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.

Cardiovascular Diseases Clinical Trial

— VIGILANCE  

Official title:

Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT03963271
• Other study ID #: NL67079.068.18
• Status: Enrolling by invitation
• Start date: April 10, 2019
• Est. completion date: April 10, 2023

Study information

• Verified date: July 2021
• Source: Maastricht University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific genetic mutations regarding sudden cardiac death or sudden cardiac arrest, in their family members and in a control cohort. The electrophysiological properties will be measured with the relatively new technique ECG-Imaging (ECGI).

Also a National Dutch registry for patients with unexplained polymorphic VT and/or VF and their family members will be created.

By combining the data from the registry and the results of ECGI, The investigators hope to identity risk markers for patients at higher risk for apparently idiopathic ventricular fibrillation, and use these for an adapted flow chart for the 'general'population of patients at risk for unexplained polymorphic VT and/or VF. The investigators aim to be able to identify patients before the first arrhythmic event, and aim for better treatment strategies in the future.

Description:

ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal cardiac electrophysiology, but also electrophysiological disorders and disease. The results strongly suggest that ECGI can play a pivotal role in further characterizing arrhythmia mechanisms, therefore could do so for polymorphic VT or idiopathic VF leading to diagnosis and treatment improvement. Moreover, ECGI seems to have the potential to detect arrhythmogenic substrate in individuals before their first event, offering the possibility to diagnose and treat patients before sudden cardiac arrest occurs.

In the VIGILANCE study:

1. ECGI will be used to noninvasively characterize the epicardial electrophysiological substrate and triggers of:

• Patients with unexplained polymorphic VT and VF,

• Index patients of family cohorts with a specific genetic mutation related to arrhythmogenesis, at high risk for unexplained polymorphic VT and/or VF.

• Family members,

• A control cohort. Results will be evaluated for risk stratification.

2. All unexplained polymorphic VT and/or VF patients and their family members will be asked to participate in a National Dutch registry, and these date will be analysed to determine their prognostic value in terms of arrhythmia risk

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 500
• Est. completion date: April 10, 2023
• Est. primary completion date: April 10, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

In order to be eligible to participate in this study, a subject must be = 18 years old and meet one of the following criteria:

• All unexplained polymorphic VT or VF survivors in whom known structural myocardial, respiratory, metabolic and toxicological causes have been excluded through clinical evaluation", with/without a genetic mutation. NB. If results of a diagnostic tests show minor abnormalities but insufficient for a specific diagnosis, this is no exclusion criterion.

• Selected family members of these patients*

• Control subjects with structurally normal hearts with a clinical indication for a cardiac CT scan.

• All 1st and 2nd degree family members being in contact with the cardiologist/treating physician as part of cascade screening will be contacted as described in chapter 11.2.2.

Family members must be in adequate health to be able to travel to the hospital for research purposes.

3rd degree family members can also be contacted as described in chapter 11.2.2 if at least one of the following criteria is met:

• The family member has the same genetic mutation as index patient, or;

• The family member has demonstrated ventricular arrhythmias, or;

• The clinician has a very strong suspicion of ventricular arrhythmias in the family member.

Exclusion Criteria:

A potential subject who meets any of the following criteria will be excluded from participation in this study:

• A known strong reaction against electrode attachment or contrast agent.

• Any serious medical condition, which in the opinion of the investigator, may adversely affect the safety and/or effectiveness of the participant or the study.

• Pregnancy, nursing or planning to be pregnant.

• Subject has an estimated glomerular filtration rate (eGFR) of <30mL/min/1.73m2

, using the MDRD calculation

• Unability to give informed consent.

• Family members of patients with unexplained polymorphic VT/VF, who have severe cardiac abnormalities and/or disease not related to the symptoms or phenotype of the index patient, and which may have a negative influence on results of ECGI according to local investigators.

Related Conditions & MeSH terms

• Arrhythmias, Cardiac
• Cardiac Arrest
• Cardiac Arrhythmia
• Cardiovascular Diseases
• Death
• Death, Sudden, Cardiac
• Genetic Disease
• Genetic Diseases, Inborn
• Heart Arrest
• Idiopathic Ventricular Fibrillation
• Polymorphic Ventricular Tachycardia
• Sudden Cardiac Death
• Tachycardia
• Tachycardia, Ventricular
• Ventricular Arrythmia
• Ventricular Fibrillation

Intervention

Diagnostic Test:
• ECG-Imaging
A body surface potential mapping and a cardiac + low dose CT-scan.

Locations

Country	Name	City	State
Netherlands	Amsterdam University medical Centre, location AMC	Amsterdam
Netherlands	Maastricht Universite Medical Centre	Maastricht	Nederland
Netherlands	University Medical Centre Utrecht	Utrecht

Sponsors (4)

Lead Sponsor	Collaborator
Maastricht University Medical Center	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Heart Foundation, UMC Utrecht

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ECG-Imaging outcome: epicardial potentials	reconstructed epicardial potentials, represented in mV over time(s).	3 years
Primary	ECG-Imaging outcome: activation and repolarization maps	Activation and repolarization maps. These are made by measuring acivation and repolarization times from the reconstructed potentials in miliseconds. Then local activation and recovery times are plotted on a CT-derived heart mesh. The entire activation and repolarization of the epicardium of the heart can be visualized this way.	3 years
Secondary	(Possible) Prognostic risk factors for recurrent ventricular arrhythmias	possible risk factors, found in the registry, given as odds/hazard ratio.	3 years
Secondary	Recurrence of ventricular arrhythmias	documentation over the period of follow-up, if studysubjects had a recurrence of ventricular arrythmia(s), presented as number of events over a time period.	3 years