Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

Cardiovascular Diseases Clinical Trial

Official title:

High-intensity Interval Training Versus Moderate Intensity Continuous Training as a Means to Improve Cardiometabolic Health After Spinal Cord Injury

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03808363
• Other study ID #: 18-022-DITOR
• Status: Completed
• Phase: N/A
• Start date: February 1, 2019
• Est. completion date: December 15, 2019

Study information

• Verified date: January 2020
• Source: Brock University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

Description:

This study aims to challenge the effectiveness of the current aerobic exercise recommendations for individuals with spinal cord injuries (SCI). Currently, moderate intensity continuous training (MICT) is suggested however this study intends to explore the effectiveness of high intensity interval training (HIIT). To do so, approximately 8 individuals with SCI will be undergo a 6 week HIIT intervention consisting of 3 sessions per week. With a focus on cardiometabolic health markers (listed in outcome measure section), we aim to provide support for HIIT as a viable method of mitigating cardiovascular risk in a SCI population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: December 15, 2019
• Est. primary completion date: May 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury.

• Declared medically stable, and able to communicate clearly in English.

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Metabolic Syndrome

Intervention

Other:
• High Intensity Interval Training
Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light - very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks.

Locations

Country	Name	City	State
Canada	Brock University	St. Catherines	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Brock University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Waist circumference (inches)	Central adiposity will be measured by tape measure to monitor possible weight loss	6 weeks
Primary	Cholesterol	Total and HDL cholesterol will be measured in serum	6 weeks
Primary	Triglycerides	Triglycerides will be measured in serum	6 weeks
Primary	Glycated Hemoglobin (HbA1c)	Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk	6 weeks
Primary	Tumor necrosis factor (TNF-a)	TNF-a will be used as an inflammatory representative and will be measured in serum	6 weeks
Primary	Interleukin - 10 (IL-10)	IL-10 will will be used as an anti-inflammatory representative and will be measured in serum	6 weeks
Primary	Pulse Wave Velocity	Arterial stiffness, a common measure for cardiac risk will be measured	6 weeks
Primary	Blood pressure	Measured through a digital cuff, the focus will be on both systolic and diastolic	6 weeks
Primary	Peak Oxygen Consumption (VO2 peak)	VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness	6 weeks
Primary	C Reactive Protein (CRP)	CRP will will be used as an inflammatory representative and will be measured in serum	6 weeks
Primary	Leptin	Leptin will will be used as a body fat representative and will be measured in serum	6 weeks
Primary	Adiponectin	Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum	6 weeks
Secondary	Physical Activity Enjoyment Scale (PACES)	All participants will complete the physical activity enjoyment scale (PACES) to indicate enjoyment of HIIT. With a total of 18 questions, options 1 through 7 going from a positive to a negative overall experience with the HIIT protocol will be documented.	6 weeks