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Study to Evaluate the Effects of MEDI6012 on Apolipoprotein B100 Metabolism

Cardiovascular Diseases Clinical Trial

Official title:
Study to Evaluate the Effects of Two Doses Over 48 Hours of MEDI6012 on Apolipoprotein B100 Metabolism in Subjects With Stable Atherosclerotic Cardiovascular Disease

Clinical Trial Summary

This is a Phase 2, single-center, placebo controlled, double-blind, randomized crossover study to determine the effects of MEDI6012 on the metabolism of apolipoprotein B100 (apoB100) lipoproteins in individuals with stable atherosclerotic cardiovascular disease (ASCVD).

Clinical Trial Description

Atherosclerosis, characterized by excess fat deposit in arteries, is a progressive and life-threatening condition. Therefore, treatments that can remove fat deposits from the arteries are being developed. These treatments may prevent subsequent heart attacks or other cardiovascular events, addressing an unmet medical need. MEDI16012 is a new drug that targets a substance produced by the body to assist participants in breaking down the bodies "good" fat. The investigators are interested in understanding why MEDI6012 increases the good fat, but also why it increases other types of "bad" fat such as low-density lipoprotein-C (LDL-C). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03773172
Study type Interventional
Source Columbia University
Contact
Status Terminated
Phase Phase 2
Start date January 31, 2019
Completion date May 20, 2020
View Details
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