The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

Cardiovascular Diseases Clinical Trial

Official title:

The Effects of Aerobic Exercise Training in Patients With Cardiovascular Diseases Related to Microvascular Endothelium Function, Angiogenesis, Oxidative Stress and Aerobic Capacity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02514564
• Other study ID #: Faperj-E-26/101.575
• Status: Completed
• Phase: N/A
• First received: July 30, 2015
• Last updated: March 1, 2017
• Start date: December 2014
• Est. completion date: December 2016

Study information

• Verified date: March 2017
• Source: Instituto Nacional de Cardiologia de Laranjeiras
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Description:

Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 115
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• sedentarism for at least 6 months;

• clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion Criteria:

• nephropathies;

• decompensated cardiovascular diseases;

• liver diseases.

Related Conditions & MeSH terms

• Cardiovascular Diseases

Intervention

Behavioral:
• Exercise
Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

Locations

Country	Name	City	State
Brazil	Instituto Nacional de Cardiologia	Rio de Janeiro	RJ

Sponsors (1)

Lead Sponsor	Collaborator
Instituto Nacional de Cardiologia de Laranjeiras

Country where clinical trial is conducted

Brazil, 

References & Publications (2)

Cordovil I, Huguenin G, Rosa G, Bello A, Köhler O, de Moraes R, Tibiriçá E. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvasc Res. 2012 May;83(3):376-9. doi: 10.1016/j.mvr.2012.01.004. — View Citation

Souza EG, De Lorenzo A, Huguenin G, Oliveira GM, Tibiriçá E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coron Artery Dis. 2014 Jan;25(1):23-8. doi: 10.1097/MCA.0000000000000055. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in Skin microvascular blood flow	Measured through a Laser Speckle Contrast Imaging equipment	Change from baseline in skin microvascular blood flow at 6 months
Secondary	Change in peak oxygen consumption	Measured at a maximal graded exercise test	Change from baseline in peak oxygen consumption at 6 months
Secondary	Change in weight	Measured with a calibrated digital scale	Change from baseline in weight at 6 months