Cardiovascular Diseases Clinical Trial
Official title:
The Role of EGCG in Different Application Forms on Flow-mediated Dilation in Healthy Volunteers
Cardiovascular diseases are a major cause of morbidity and mortality worldwide. Impaired
endothelial function (assessed as flow-mediated dilation) represents an early marker for
later cardiovascular events. Epidemiological and experimental studies suggest that
consumption of tea is associated with lower progression of atherosclerosis and reduced
cardiovascular mortality.
Tea contains high amounts of polyphenols with important biological activities. The green tea
catechin epigallocatechin-3-gallate (EGCG) is the most potent physiologically active
compound in vitro. However, little is known about its contribution to beneficial effects of
tea in vivo.
In this crossover study the impact of a single dose of EGCG applied in different forms
(green tea beverage, green tea extract and EGCG) on flow-mediated dilation is investigated
in healthy volunteers two hours after ingestion. The amount of EGCG (200 mg) corresponds to
appr. 0.5 L of green tea. The results of the study will elucidate the contribution of EGCG
in cardiovascular protective effects of green tea in vivo. The outcomes will provide
insights about the role of EGCG in different application forms to improvements of
endothelial function in humans.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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