Cardiovascular Diseases Clinical Trial
To investigate the role of endothelial dysfunction and increased vascular stiffness as contributors to the pathogenesis of cardiovascular disease.
BACKGROUND:
Increasingly, researchers understand that endothelial dysfunction and increased vascular
stiffness contribute to the pathogenesis of cardiovascular disease (CVD). The Framingham
Heart Study (FHS) has been examining vascular function in about 3600 middle-aged and elderly
participants of the FHS Offspring and minority OMNI cohorts.
DESIGN NARRATIVE:
The study characterizes vascular function by performing noninvasive studies of endothelial
function with brachial ultrasound flow-mediated dilation, and of vascular stiffness with
arterial tonometry, in 3850 adult offspring of the FHS Offspring and OMNI cohorts. The total
of over 7000 vascular examinations in an extensively studied multi-generational
community-based cohort provides the opportunity to characterize the environmental and
genetic determinants, and the prognosis of altered vascular function. The study hypotheses
are: vascular function is determined by both environmental and genetic factors; endothelial
function and vascular stiffness phenotypes are associated with each other: and vascular
dysfunction predisposes to the development of hypertension (HTN) and cardiovascular disease.
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