Cardiovascular Diseases Clinical Trial
To relate cardiovascular disease (CHD) risk factors to cognitive performance among middle-aged and elderly men and women over a 10 year longitudinal study period.
BACKGROUND:
The Framingham Heart Study is a major epidemiological investigation of prospective
relationships between risk factors for the development of cardiovascular disease (CVD risk
factors) and CVD risk factor outcomes. The Framingham Study and other large, prospective
studies have resulted in an extensive literature on the impact of CVD risk factors
(including age) and CVD outcomes. Comparatively, there have been many fewer studies of the
impact of CVD risk factors on cognitive functioning, and possibly no studies of the effect
of objectively measured, competing risk factors on cognitive functioning.
DESIGN NARRATIVE:
Dr. Elias and colleagues used cardiovascular risk factor data from the Framingham Heart
Study (N= 2,123) in a prospective design allowing them to relate CVD risk factors (including
age and gender) to two outcome measures: (1) level of cognitive performance and (2) change
in cognitive performance over a 10 year longitudinal study period. The overall goals were to
determine the best multivariate combination of biological and psychosocial risk factors for
the prediction of lowered cognitive ability in middle-aged and elderly men and women, and to
evaluate the relative impact of age, gender, and other biological and psychosocial risk
factors on cognitive functioning.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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