Cardiovascular Diseases Clinical Trial
To conduct gene mapping studies for quantitative traits.
DESIGN NARRATIVE:
The study built upon existing sib-pair methods for multipoint mapping of Quantitative Trait
Loci (QTL)s. It greatly expanded upon the statistical methodology to identify and localize
QTLs for complex traits by merging sib-pair methods with a powerful twin design which used
phenotypic data on monozygotic (identical) and dizygotic (fraternal) twins to resolve
phenotypic variability into genetic and non-genetic components, and partition human
quantitative genetic variation into effects due to loci on specific chromosomal regions.
This quantitative methodology was applied to risk factors for cardiovascular disease -- one
of the most pressing health problems in Western society. Population-based samples of Dutch,
Swedish, and Australian twins had been identified in previous studies, phenotypic measures
on lipids, lipoproteins, and other important cardiovascular risk factors had been obtained,
and blood had been banked in a valuable resource which was available for use in this study.
In 500 DZ twin pairs, a series of 175 highly polymorphic microsatellite markers were
detected using an automated process for detecting fluorescent signals. These data were
analyzed using the new statistical methods both to confirm the effects of a series of
candidate loci and to test for the effects of previously unknown QTLs.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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