Cardiovascular Diseases Clinical Trial
To develop TI (pronounced 'T-sub-I'), a personal computer program to analyze time-varying data generated by periodic patient reports, repeatedly-observed disease signs, or serial biomarkers to study chronic disease.
BACKGROUND:
With the advent of quasi-likelihood, generalized estimating equations, and new ways to
handle missing data, has come a striking increase in applicable models, perhaps more than
after the 1972 introduction of the Cox model for survival data. TI provided a way to analyze
the data.
DESIGN NARRATIVE:
TIl provided graphics for data exploration and model validation. TI ran under most current
version of Windows, used Civilized Software's MLAB as its programming language, offered
context-sensitive help, a dictionary of relevant terms, identification of file entries from
their screen position, and simple animation. TI permitted the user to analyze time-varying
data from the two perspectives of repeated measured using a variety of models and time
series where both time and frequency domain tools were provided.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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