The Influence of Aerobic Exercise on Serum Brain Natriuretic Peptide and C- Reactive Protein in Cardiovascular Disease

Cardiovascular Disease Clinical Trial

— AEBNPCRP  

Official title:

The Influence of Aerobic Exercise on Serum Brain Natriuretic Peptide and C- Reactive Protein in Cardiovascular Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02479269
• Other study ID #: CT-P-92-6517
• Status: Completed
• Phase: N/A
• First received: June 13, 2015
• Last updated: June 19, 2015
• Start date: March 2015
• Est. completion date: May 2015

Study information

• Verified date: June 2015
• Source: Islamic Azad University, Shiraz
• Contact: n/a
• Is FDA regulated: No
• Health authority: Shiraz University of Medical Sciences,Country:Islamic Republic of Iran
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to investigate the effects of 8 weeks of aerobic exercise on serum concentrations of Brain Natriuretic Peptide and C - reactive protein in patients with cardiovascular disease. Patients were divided randomly into two groups: control and experimental aerobic group. This study was done with two - stage blood sampling: at the beginning and at the end of the treatment phase. All subjects were requested to avoid any exercise at least 48 hours before blood sampling. To study Brain Natriuretic Peptide and C - reactive protein changes, 5 milliliters of blood were taken from patient's brachial vein. Blood samples for subsequent measurements were frozen immediately and transported to the Hormone Laboratory for serum separation. The experimental group did the aerobic exercise programs for 8 weeks for 3 sessions per week and the control group did not receive any training. After completion of training, the final blood samplings were performed. Exercise intensity according to the heart rate remained stable until the last week. Brain Natriuretic Peptide and C - reactive protein levels were measured by ELISA tests. All statistical analysis were done using SPSS software (version 16) and at the significance level of p≤ 0.05

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: May 2015
• Est. primary completion date: May 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 65 Years

Eligibility

Inclusion Criteria:

• In this trial patients with coronary artery disease more than 70 percent at least in one coronary vessel with Ejection Fraction more than 40 percent in recent Echo cardiograph without acute evidence of ischemia or congestive heart failure symptoms were selected and are divide randomly into two groups.

Exclusion Criteria:

• Patients with acute evidence of ischemia or congestive heart failure symptoms are excluded.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Cardiovascular Disease
• Cardiovascular Diseases

Intervention

Other:
• Aerobic exercise
Aerobic exercise for 8 weeks

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Islamic Azad University, Shiraz	Shiraz University of Medical Sciences

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain Natriuretic Peptide		8 weeks	Yes
Primary	serum C - reactive protein		8 weeks	Yes
Secondary	serum lipoproteins		8 weeks	Yes
Secondary	Body Mass Index		8 weeks	Yes
Secondary	blood pressure		8 weeks	Yes