Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients

Cardiovascular Disease Clinical Trial

Official title:

Prevalence Of Hyperhomocysteinemia In Thai CKD Patients And Relationship To Cardiovascular Events: Subgroup Analysis From Thai SEEK Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01391416
• Other study ID #: VJR-0002
• Status: Completed
• Phase: N/A
• First received: July 8, 2011
• Last updated: July 11, 2011
• Start date: June 2010
• Est. completion date: January 2011

Study information

• Verified date: May 2010
• Source: Bangkok Metropolitan Administration Medical College and Vajira Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand:Ethics Committee for Researches Involving Human Subjects ,The Bangkok Metropolitan Administration
• Study type: Observational

Clinical Trial Summary

It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.

Description:

Ninety eight subjects were sampling from Thai SEEK study database Traditional Traditional risk factors of CVD such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. Stored sera of these subjects were analyzed for the total homocysteine (tHcy) level. Analysis of variance was used to evaluate the different of mean tHcy among groups

Recruitment information / eligibility

• Status: Completed
• Enrollment: 98
• Est. completion date: January 2011
• Est. primary completion date: November 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• CKD stages 3-4 from Thai SEEK Study

Exclusion Criteria:

• CKD stage 5

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Cardiovascular Disease
• Cardiovascular Diseases
• Hyperhomocysteinemia
• Renal Insufficiency, Chronic

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Bangkok Metropolitan Administration Medical College and Vajira Hospital

References & Publications (1)

Ingsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P, Gojaseni P, Kiattisunthorn K, Ongaiyooth L, Vanavanan S, Sirivongs D, Thirakhupt P, Mittal B, Singh AK; Thai-SEEK Group. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant. 2010 May;25(5):1567-75. doi: 10.1093/ndt/gfp669. Epub 2009 Dec 27. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Level of Homocysteine	Level of homocysteinemia according to each CKD level	3 months	Yes
Secondary	Association of cardiovascular event to the level of homocysteine	Hugh level of homocysteine will have association with cardiovascular events or not	3 months	Yes

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