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NCT01236820 Clinical Trial

A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients

Cardiovascular Disease Clinical Trial

— L5  

Official title:
L5 as a Risk Factor of Cardiovascular Disease in Chronic Kidney Disease and Dialysis Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01236820
Other study ID # CTCHANG001
Secondary ID
Status Recruiting
Phase N/A
First received November 5, 2010
Last updated November 8, 2010
Start date September 2010

Study information
Verified date November 2010
Source China Medical University Hospital
Contact Chiz-Tzung Chang, Ph.D.
Phone 886-4-22052121
Email D19863@mail.cmuh.org.tw
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.

Description:

Cardiovascular disease (CVD) is the most important cause of death of chronic kidney disease (CKD) and hemodialysis (HD) patients. Low Density Lipoprotein (LDL) is an essential indicator of CVD.The higher the plasma LDL level, the higher the risk of CVD. LDL is a heterogenous substance composed of different mass and size. Oxidized LDL (oxLDL) is the oxidation product of LDL and is the most important component of LDL associated with CVD. The oxLDL is mostly trapped within tissue and not easily to be detected from blood. L5 iw a kind of electronegative LDL and is associated with CVD in smokers and diabetic patients, even if these patients have normal plasma LDL. Uremia patients have lipid profile different from that of general people,while HD Patients have lower LDL and CKD patients have LDL higher than that of general population. Thus LDL plasma level cannot fully explain the high risk of CVD in CKD and HD patients. As patients with normal LDL but high L5 are prone to have CVD, we suspect there might be association of L5 with CVD in both CKD and HD patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 48
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 20 Years and older
Eligibility Inclusion Criteria:

- clinical diagnosis of CKD

- clinical diagnosis of HD

Exclusion Criteria:

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan China Medical University Hospital Taichung City

Sponsors (1)
Lead Sponsor Collaborator
China Medical University Hospital

Country where clinical trial is conducted

Taiwan, 

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