Growth Hormone's Effect on Endothelial Progenitor Cells

Status Completed

Clinical Trial Summary

To assess the effect of short-term low-dose growth hormone therapy on the mobilization of endothelial progenitor cells from the bone marrow within a group of healthy adults.

Clinical Trial Description

We are proposing a pilot study to assess the effect of the administration of recombinant human growth hormone on the number of endothelial progenitor cells (EPC’s) in the peripheral circulation. An increase in the number of EPC’s is viewed as beneficial, as it has been postulated that they provide an endogenous repair mechanism to counteract endothelial injury. Additionally, a reduced number of EPC’s has been found to independently predict atherosclerotic disease progression. Mechanisms proposed for enhancing the number of circulating EPC’s and their function include an increase in proliferation, mobilization from the bone marrow, or prevention of EPC apoptosis. Thus, a pharmacologic manipulation of the number of EPC’s in the peripheral circulation could potentially serve as a mechanism by which endothelial function, and thus vascular health, may be improved. ;

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00397592
Study type	Interventional
Source	Vanderbilt University
Contact
Status	Completed
Phase	N/A
Start date	August 2006
Completion date	January 2007

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