Cardiovascular Disease Clinical Trial
Official title:
A Pilot Study of B-Type Natriuretic Peptide (BNP) Levels in Patients With Congenital Heart Disease and Systemic Right Ventricles or Volume Overloaded Pulmonic Right Ventricles
The object of this study is to measure the levels of B-type Natriuretic Peptide (BNP) in patients with congenital heart disease, normal individuals, and patients with acquired heart failure, and compare the results from each group.
Enrollment: Patients with congenital heart disease seen at Emory Clinics, Adult Congenital
Heart Disease program, Crawford Long Hospital will be asked to participate in this pilot
study. Sample size: 20 patients (5 in each group) Screening Phase: Demographic data, medical
history, physical examination including vital signs and room air oxygen saturation, and
medications will be recorded. New York Heart association functional class will be recorded.
BNP Levels: Approximately 7 cc of blood will be collected. The blood will be analyzed for
B-type natriuretic peptide on a rapid assay in the clinic.
Exercise Tolerance: will be measured by a 6 minute walk test on day of visit Echocardiogram:
A complete echocardiogram including assessment of anatomy, ventricular function and valvular
function will be performed following the phlebotomy.
Quality of life: The minnesota living with heart failure questionnaire will be administered
on the day of collection of neurohormonal levels. A research nurse will be available to
assist the patient if needed.
;
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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