Cardiovascular Disease Clinical Trial
Official title:
Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy
The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.
The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12
weeks of resistance exercise training for the purpose of inducing skeletal muscle
hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a
double-blind design to test the hypothesis that dietary cholesterol is essential for
skeletal muscle hypertrophy. If so proven, this will confirm a very strong association
between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women
(age 60-69). The current proposal is using a randomized double-blind, placebo controlled
design to provide the most conclusive evidence that dietary cholesterol plays an essential
role in skeletal muscle hypertrophy.
The secondary objective of this proposal is to test the hypothesis that increased dietary
cholesterol consumption in the context of an exercise program does not alter blood
cholesterol concentrations or other cardiovascular risk factors.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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