Scrub Typhus Infection Induced Cardiovascular Disease

Cardiovascular Complication Clinical Trial

Official title:

Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03274869
• Other study ID #: EMC 2017-07-006-001
• Status: Completed
• Start date: September 1, 2017
• Est. completion date: August 30, 2023

Study information

• Verified date: February 2024
• Source: Eulji University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Description:

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: August 30, 2023
• Est. primary completion date: August 30, 2023
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

• any participants with scrub typhus infection

Exclusion Criteria:

• patients under age of 18

• pregnancy

Related Conditions & MeSH terms

• Cardiovascular Complication
• Cardiovascular Diseases
• Scrub Typhus

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
Korea, Republic of	Chung-Buk University Hospital	Chungju	Chung Chung Do
Korea, Republic of	Chung-Nam University Hospital	Daejeon	Chung Chung Do

Sponsors (3)

Lead Sponsor	Collaborator
Eulji University Hospital	Chungbuk National University Hospital, Chungnam National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (3)

Chin JY, Kang KW, Moon KM, Kim J, Choi YJ. Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. Korean J Intern Med. 2018 Mar;33(2):323-330. doi: 10.3904/kjim.2016.303. Epub 2017 Feb 23. — View Citation

Jang SY, Kang KW, Kim JH, Kim B, Chin JY, Park SH, Choi YJ, Jung KT, Lee SK. New-onset atrial fibrillation predicting for complicating cardiac adverse outcome in scrub typhus infection. Clin Cardiol. 2019 Dec;42(12):1210-1221. doi: 10.1002/clc.23276. Epub — View Citation

Kang KW, Hong KW, Lee SK. Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing. Korean J Intern Med. 2023 Nov;38(6):865-871. doi: 10.3904/kjim.2023.221. Epub 2023 Nov 1. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cardiovascular Mortality	Cardiovascular death including sudden cardiac death	one year
Secondary	Cardiovascular Complications	Atrial Fibrillation, Acute Heart Failure including acute myocarditis and Ischemic Heart Dease	one year