Scrub Typhus Infection Induced Cardiovascular Disease

Cardiovascular Complication Clinical Trial

Official title: Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection

Status Completed

Clinical Trial Summary

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Clinical Trial Description

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea. ;

Related Conditions & MeSH terms

• Cardiovascular Complication
• Cardiovascular Diseases
• Scrub Typhus

• NCT number: NCT03274869
• Study type: Observational
• Source: Eulji University Hospital
• Status: Completed
• Start date: September 1, 2017
• Completion date: August 30, 2023