Cardiovascular Diseases Clinical Trial
Official title:
Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
The study will investigate whether a new high resolution heart Magnetic Resonance Imaging scan, combining assessment of ischemia and viability by perfusion and Late Gadolinium Enhancement -Cardiac Magnetic Resonance is superior to Late Gadolinium Enhacement imaging alone in predicting functional recovery following revascularisation.
Coronary artery disease, where the heart's blood supply is restricted by narrowings or
blockages, is the commonest cause of heart failure. This condition is called ischaemic
cardiomyopathy. In some patients, treating these narrowings/ blockages with by-pass surgery
or stents, known as "revascularisation", helps improve the pumping strength of the heart but
it is currently difficult to predict which patients will benefit. The best test the
investigators currently have to predict who will benefit from revascularisation is an
Magnetic Resonance Imaging scan of the heart which looks for how much the heart has been
scarred. Hearts with no scar usually improve after revascularisation and hearts with lots of
scar usually do not. However, lots of patients fall into the middle and have moderate amounts
of scar. The Magnetic Resonance Imaging scan isn't good at predicting if this group of
patients will benefit from revascularisation. Revascularisation procedures, including heart
by-passes, are not without risk and often require time in intensive care, several days in
hospital and a long recovery period at home. If the investigators can develop a better test
which is more accurate at predicting whether hearts with moderate scar will improve then they
will be able to provide better care for patients by ensuring only those patients who will get
benefit from revascularisation are put through the procedure.
This study will investigate whether a new high-resolution heart Magnetic Resonance Imaging
scan, which looks at not only levels of scar but also the quality of blood supply, is more
accurate than current MRI scans at predicting heart recovery after revascularisation in
patients with moderate amounts of scar.
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