Clinical Trials Logo
  1. Home
  2. Other
  3. NCT03540563

ctDNA as a Biomarker for Treatment Response in HNSCC — PECAN  

Carcinoma, Squamous Cell of Head and Neck Clinical Trial

Official title:
Prospective Study Evaluating ctDNA as a Biomarker for Treatment Response in Head and Neck Squamous Cell Carcinoma'

Clinical Trial Summary

Tumours continually shed DNA into the circulation, where it can be accessed. This circulating tumour DNA (ctDNA) directly reflects tumour burden and has great potential to be a sensitive biomarker for treatment recurrence. These "liquid biopsies" could give a more real-time picture of the genomic status and evolution of a tumour and can be easily assessed for measurement of different biomarkers. However, in head and neck squamous cell carcinoma (HNSCC) patients treated with primary curative radiotherapy, data regarding ctDNA kinetics and its correlation with outcome are scarce. A new or additional tool for response evaluation next to or instead of conventional imaging after treatment would be beneficial to detect recurrences in an earlier stage, thereby increasing the chances of success of salvage therapy. More importantly, an early response parameter during treatment could help to identify patients that have a good treatment response and might benefit from treatment adaptation. With this study, we aim to reveal ctDNA as an effective tool for future dose (de)-escalation trials in HNSCC.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03540563
Study type Interventional
Source The Netherlands Cancer Institute
Contact
Status Completed
Phase N/A
Start date July 16, 2018
Completion date August 1, 2023
View Details
See also
  Status Clinical Trial Phase
Completed NCT02113878 - Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck Phase 1
Active, not recruiting NCT03291002 - Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC Phase 1
Terminated NCT02277184 - Ficlatuzumab, Cisplatin and IMRT in Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 1
Completed NCT01080066 - A Post Marketing Surveillance Study of Cetuximab in Patients With Squamous Cell Carcinoma of Head and Neck (SCCHN) N/A
Completed NCT02585973 - Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC Phase 1
Completed NCT01836029 - Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Phase 2
Active, not recruiting NCT03715946 - Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer Phase 2
Active, not recruiting NCT03088059 - Biomarker-based Study in R/M SCCHN Phase 2
Recruiting NCT06003231 - A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2 Phase 2
Terminated NCT02438995 - Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck Phase 1
Completed NCT02242916 - State of the Art Photon Therapy Versus Particle Therapy for Recurrent Head & Neck Tumors; a Planning Study N/A
Recruiting NCT01876693 - A Prospective Study of Prophylactic Gastrostomy in Head and Neck Cancer Patients Undergoing Chemoradiotherapy N/A
Terminated NCT02655068 - Phase III Trial of PET/CT vs. CTSurveilance for Head and Neck Cancer Phase 3
Active, not recruiting NCT03509012 - Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors Phase 1
Active, not recruiting NCT02296684 - Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma Phase 2
Active, not recruiting NCT03799744 - Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell Carcinoma Phase 1
Completed NCT03109158 - NC-6004 With 5-FU and Cetuximab for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Phase 1/Phase 2
Recruiting NCT03485209 - Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors Phase 2
Completed NCT01307267 - A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab Phase 1
Terminated NCT02822482 - Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss Phase 1/Phase 2