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Cannabis clinical trials

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NCT ID: NCT03994640 Completed - Clinical trials for Temporomandibular Disorder

Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD

Start date: January 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD

NCT ID: NCT03699540 Completed - Alcohol Drinking Clinical Trials

Marijuana Effects on Simulated Driving Performance

Start date: July 1, 2019
Phase: Phase 1
Study type: Interventional

This study will examine the effects of various strains of marijuana on simulated driving performance; the effects of alcohol administration will also be examined to further understand how marijuana-induced driving changes compare to the effects of alcohol. Secondary outcomes will include physiological effects, subjective- and observer-rated outcomes, and psychomotor performance under the various dose conditions.

NCT ID: NCT03681353 Completed - Cannabis Use Clinical Trials

Impact of Reduced Cannabis Use on Functional Outcomes

Start date: April 4, 2019
Phase: N/A
Study type: Interventional

Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007. Heavy cannabis use is associated with lower educational attainment, reduced physical activity, and increased rates of addiction, unemployment, and neuropsychological deficits. Studies by the lab and others suggest that cannabis use is also associated with increased mental health symptoms and suicidal and nonsuicidal self-injury. In addition, cannabis is the illicit drug most strongly associated with drugged driving and traffic accidents, including fatal accidents. There is evidence that sustained abstinence from cannabis can lead to improvements in the functional outcomes of former users. However, he degree to which reductions in cannabis use might be associated with positive changes in functional outcomes is currently unknown. The overall objective of the present research is to use ecological momentary assessment (EMA), a real-time, naturalistic data collection method, to study the impact of reduced cannabis use on functional outcomes in heavy cannabis users. Contingency management (CM) will be used to promote reductions in frequency and quantity of cannabis use. CM is an intensive behavioral therapy that is highly effective at producing short-term reductions in illicit drug use. The investigators novel approach includes mobile technology to make CM more portable and feasible. The present research will use this technology in conjunction with state-of-the-art EMA methods to study the impact of reduced cannabis use on key functional outcomes. The investigators central hypothesis is that reductions in frequency and quantity of cannabis use will lead to positive changes in cannabis users' mental health, physical activity, working memory, health-related quality of life, and driving behavior.

NCT ID: NCT03676166 Completed - Cannabis Clinical Trials

Pharmacokinetic and Pharmacodynamic Effects of Smoked and Vaporized Cannabis

Start date: June 16, 2016
Phase: Phase 1
Study type: Interventional

Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of smoked and vaporized cannabis. Careful analysis of different cannabis administration methods on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. In the present study the investigators evaluated the detection of cannabinoids in whole blood, oral fluid, and urine, as well as the acute pharmacodynamics associated with smoked and vaporized cannabis among individuals who were not regular cannabis users. The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of smoked and vaporized cannabis administration and can inform policies regarding clinical, workplace and roadside drug testing programs.

NCT ID: NCT03560934 Active, not recruiting - Sleep Clinical Trials

Tetrahydrocannabinol (THC) and Sleep

Start date: September 1, 2018
Phase: Early Phase 1
Study type: Interventional

The investigators will test the effects of 10-60mg dronabinol (oral THC) on sleep in non-frequent and frequent cannabis users.

NCT ID: NCT03555968 Withdrawn - Alcohol Drinking Clinical Trials

Effects of THC and Alcohol on Driving Performance

Start date: July 2021
Phase: Phase 4
Study type: Interventional

Low blood concentrations of THC and alcohol appear to have a minimal effect on driving performance.However, there is a gap in the literature about the combined effects of THC and alcohol. There is little empirical evidence to determine whether the combination of THC and alcohol could be additive or multiplicative. This issue is particularly important when dealing with concentrations that are just below legal thresholds - it is important to identify if someone who may have consumed cannabis and alcohol, in quantities that do not exceed legal thresholds, may nonetheless be impaired to drive. Answering this question requires more research on the combined effects of THC and alcohol under tightly controlled experimental conditions. Hence, the purpose of this study is to determine the additive (or multiplicative) effect of standardized low doses of cannabis, in combination with low-doses of alcohol, on a number of outcome measures related to driving. The investigators will focus specifically on the effect of low blood concentrations of THC (0, 125, and 250 µg/kg) alone and in combination with low blood concentrations of alcohol (BAC 0%, .025%, and .049%). They shall determine the combined effect of THC and alcohol on physiological, cognitive, subjective measures of impairment, and simulated driving. This study will focus on younger adults because they have higher impaired driving rates than other age groups. As a secondary aim of the study, the investigators will examine whether previous driving and drug use history are correlated with driving decisions during the simulated drive and subjective measures. This study will contribute to the evidence base informing legislation, policy making, and law enforcement. This study is particularly timely given upcoming changes in legislation about cannabis, and because the combination of THC and alcohol, even below legal thresholds, may lead to impaired driving and crashes.

NCT ID: NCT03546790 Completed - Cannabis Clinical Trials

Laboratory Smoking of Marijuana "Blunts"

Start date: April 10, 2019
Phase: Phase 1
Study type: Interventional

This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.

NCT ID: NCT03538288 Completed - Cannabis Clinical Trials

Feasibility Trial of rTMS for Cannabis Use Disorder

Start date: October 1, 2016
Phase: N/A
Study type: Interventional

This small pilot trial will recruit 10 cannabis use disordered participants and apply 20 sessions of rTMS in conjunction with a two session Brief Marijuana Dependance Counseling treatment paradigm. The investigators are primarily seeking to determine if the proposed paradigm is feasible and well tolerated.

NCT ID: NCT03467620 Withdrawn - Crohn Disease Clinical Trials

Cannabidiol Usage as an Adjunct Therapy for Crohn's Disease

Start date: July 2018
Phase: Phase 2/Phase 3
Study type: Interventional

To date, few studies have assessed the efficacy and safety of Cannabinoids, compounds derived from the Cannabis plant, in patients with Crohn's disease. Our study seeks to pilot a randomized, placebo-controlled trial assessing the efficacy and safety of oral cannabinoids as an adjunct therapy in patients with Crohn's disease.

NCT ID: NCT03251326 Terminated - Clinical trials for Post Traumatic Stress Disorder

Nabilone in Cannabis Users With PTSD

Start date: October 2015
Phase: Phase 1/Phase 2
Study type: Interventional

Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown. The purpose of this placebo-controlled, within-subject study is to assess the effects of smoked cannabis and orally administered nabilone, a synthetic analog of THC, the primary psychoactive component of cannabis on multiple dimensions of PTSD symptomatology in cannabis smokers with PTSD.