Feasibility Trial of rTMS for Cannabis Use Disorder

Status Completed

Clinical Trial Summary

This small pilot trial will recruit 10 cannabis use disordered participants and apply 20 sessions of rTMS in conjunction with a two session Brief Marijuana Dependance Counseling treatment paradigm. The investigators are primarily seeking to determine if the proposed paradigm is feasible and well tolerated.

Clinical Trial Description

The overarching goal of this proposal is to investigate if a course of excitatory DLPFC rTMS is feasible and well tolerated by a group of treatment seeking CUD patients (Aim1). The investigators are also hoping to preliminarily determine if a course of rTMS reduces cannabis cue-induced craving (Aim2). Additionally the investigators want to preliminarily explore the mechanistic underpinnings of any observed effect by collecting functional magnetic resonance imaging (fMRI) data during cannabis cue-administration before and after the treatment course (Aim 3). These aims will be addressed through an open label study in which 10 treatment seeking cannabis use disordered participants will be given 20 sessions of Active excitatory rTMS applied to the DLPFC. TMS will be delivered in an accelerated fashion over two weeks (2 sessions each day, five days each week). TMS will be applied in conjunction with a validated two-session Motivational Enhancement Therapy (MET) behavioral intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03538288
Study type	Interventional
Source	Medical University of South Carolina
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2016
Completion date	July 1, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04284813` - Families With Substance Use and Psychosis: A Pilot Study	N/A
Completed	`NCT04199468` - THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis	Phase 1
Completed	`NCT04587700` - Analgesic Consumption in Chronic Marijuana Users Following Orthopedic Trauma Surgery
Not yet recruiting	`NCT05899946` - An Integrated Program to Promote Anti-cannabis Messages	N/A
Active, not recruiting	`NCT02735954` - Colorado Marijuana Users Health Cohort
Completed	`NCT00842985` - Dronabinol Interactions in Humans	N/A
Completed	`NCT04124432` - Behavioral Pharmacology of Cannabis and Nicotine	Phase 1
Active, not recruiting	`NCT04693884` - Cannabis Inhalation: Effects on Cardiovascular Function During Rest and Exercise	Early Phase 1
Recruiting	`NCT03078309` - The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients	Early Phase 1
Active, not recruiting	`NCT03560934` - Tetrahydrocannabinol (THC) and Sleep	Early Phase 1
Recruiting	`NCT04704271` - Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II	Phase 1
Withdrawn	`NCT03245658` - The Effect of Cannabis in Pancreatic Cancer	Phase 2
Completed	`NCT04911127` - Therapeutic Response of Cannabidiol in Rheumatoid Arthritis	Phase 1/Phase 2
Not yet recruiting	`NCT05999383` - Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration	Phase 2
Recruiting	`NCT04429568` - THC Crossover Study	N/A
Active, not recruiting	`NCT05554146` - Pain Inflammation and Cannabis in HIV	N/A
Not yet recruiting	`NCT05320367` - A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users	Phase 1/Phase 2
Terminated	`NCT03251326` - Nabilone in Cannabis Users With PTSD	Phase 1/Phase 2
Completed	`NCT02567344` - Excitatory rTMS to the Left Dorsolateral Pre-Frontal Cortex to Reduce Cannabis-Cue Induced Craving	N/A
Completed	`NCT00176085` - Pharmacokinetics of THCCOOH and Its Acyl-glucuronide After Intravenous Administration of THCCOOH	Phase 1