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A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma — FIRCE-1  

Cancer Clinical Trial

Official title:
An Open-label, Multicenter Phase 2 Study Evaluating the Efficacy and Safety of Firi-cel, a CD22-directed Autologous Chimeric Antigen Receptor (CAR) T-cell Therapy in Patients With Relapsed/Refractory Large B-Cell Lymphoma After CD19-directed CAR T-cell Therapy

Clinical Trial Summary

This is a prospective, open-label, multi-center clinical study designed to evaluate the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of firicabtagene autoleucel (firi-cel), a CD22-directed autologous Chimeric Antigen Receptor (CAR) T-cell therapy for the treatment of relapsed or refractory large B-cell lymphoma (LBCL).

Clinical Trial Description

Firicabtagene autoleucel (firi-cel) is an autologous CAR T-cell therapy targeting CD22, a common B-cell antigen widely expressed in LBCL. This Phase 2 study is designed to evaluate the safety and the efficacy of firi-cel in patients with R/R LBCL that has progressed after CD19-directed CAR T-cell therapy. The study is designed to treat up to 123 patients with a single infusion of firi-cel. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05972720
Study type Interventional
Source CARGO Therapeutics
Contact CargoTx Email address
Phone (650) 499-8952
Email clinicaltrials@cargo-tx.com
Status Recruiting
Phase Phase 2
Start date August 1, 2023
Completion date December 13, 2026
View Details
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