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Clinical Trial Summary

The purpose of this research study is to find out what effects (good and bad) Pembrolizumab and radiosurgery have on participants with high-grade epidural disease of the spine.


Clinical Trial Description

Primary Objective: To determine the feasibility of patients completing stereotactic body radiation therapy and at least one (1) cycle of Pembrolizumab. Secondary Objectives: - Evaluate the radiographic response after decompressive stereotactic body radiation therapy and Pembrolizumab by calculating the improvement in thecal sac patency (see 5.2.1). - Evaluate accrual rate, - Evaluate pain relief. - Evaluate quality of life. - Evaluate cumulative incidence of adverse events. - Evaluate potential correlative blood biomarkers. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05204290
Study type Interventional
Source Wake Forest University Health Sciences
Contact Study Coordinator
Phone 336-713-3539
Email [email protected]
Status Recruiting
Phase Early Phase 1
Start date March 28, 2022
Completion date September 2023

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