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NCT05171426 Clinical Trial

Incidental Cancer in Familial Adenomatous Polyposis

Cancer Clinical Trial

Official title:
Incidental Cancer in Colectomy Specimens From Patients With Familial Adenomatous Polyposis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05171426
Other study ID # 2018/16-20
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date February 20, 2021

Study information
Verified date December 2021
Source Dr. Ersin Arslan Education and Training Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Colectomy is life-saving in patients with familial adenomatous polyposis (FAP) because cancer development is inevitable in individuals with this disease. In this study, we aimed to determine the incidence of incidental malignancy in surgical specimens from patients who underwent colectomy for FAP. Prophylactic colectomy should be performed in patients with FAP, as colorectal cancer transformation is inevitable in these individuals. The possibility of incidental cancer identified via histopathological analysis of colectomy specimens should be kept in mind in these patients.

Description:

Colectomy is life-saving in patients with familial adenomatous polyposis (FAP) because cancer development is inevitable in individuals with this disease. In this study, we aimed to determine the incidence of incidental malignancy in surgical specimens from patients who underwent colectomy for FAP. The files of patients diagnosed with FAP who underwent surgery in our clinic between 2010 and 2020 were retrospectively reviewed. Definitive surgery was performed in patients with histopathological malignancy identified in colonoscopic biopsies in the preoperative period, while prophylactic surgery was performed in patients without malignancy. The incidence of incidental malignancy in histopathological specimens from patients who underwent prophylactic colectomy was determined. Prophylactic colectomy should be performed in patients with FAP, as colorectal cancer transformation is inevitable in these individuals. The possibility of incidental cancer identified via histopathological analysis of colectomy specimens should be kept in mind in these patients.

Recruitment information / eligibility
Status Completed
Enrollment 55
Est. completion date February 20, 2021
Est. primary completion date January 15, 2019
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - diagnosed with Familial Adenomatous Polyposis Exclusion Criteria: - did not receive surgical treatment - data deficiencies

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey Dr. Ersin Arslan Training and Resource Hospital Gaziantep

Sponsors (1)
Lead Sponsor Collaborator
Dr. Ersin Arslan Education and Training Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary incidental cancer Familial Adenomatous Polyposis with cancer 2 or 3 week
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