Toxicity of Treatments for Non-tuberculous Mycobacterial Infections in Cancer Patients or Not

Cancer Clinical Trial

— MYCATRES  

Official title:

Toxicity of Treatments for Non-tuberculous Mycobacterial Infections in Cancer Patients or Not

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05030701
• Other study ID #: PI2021_843_0072
• Status: Recruiting
• Start date: July 13, 2021
• Est. completion date: October 2023

Study information

• Verified date: February 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: Jean Philippe LANOIX, MD
• Phone: 03 22 66 83 73
• Email: Lanoix.jean-philippe[@]chu-amiens.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Non-tuberculous mycobacteria (NTM) are increasingly common and have a poor prognosis: 5-year mortality can reach 40 to 50%, depending on the type of mycobacteria and the immune system of the host involved. Cancer patients are at higher risk of infectious morbidity and mortality, which may be due to disease-related immune dysfunction, immunosuppressive effects of chemotherapy, or long-term placement of a vascular catheter. However, data on the treatment of NTM species that cause infections and the disease characteristics of these pathogens in cancer patients are limited despite the growing cancer population worldwide. Recently, M. avium infections have been described in patients suffering from cancers (hematological or not), in particular in patients receiving checkpoint inhibitors. Although the proportion of M. avium pneumonia in retrospective series is low (0.8-2%), it has been shown that this population is younger, suffers less from sub-pulmonary pathology. (indicating immunosuppression in these patients) but are therefore treated less than non-cancerous subjects. This retrospective study in CHU Amiens is searching on the number of side effects of NTM treatment in two groups (cancerous and no cancerous) to assess the cause of the decrease of NTM treatment in cancerous patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 43
• Est. completion date: October 2023
• Est. primary completion date: October 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age equal or more than 18 years18
• Patients diagnosed by an infection with non-tuberculous mycobacteria according to ATS guidelines.
• Patients received the NTM treatment.

Exclusion Criteria:

• age less than 18 years
• Patients diagnosed by NTM without treatment.
• Patients with a positive sample of NTM but without infection.
• Exclusion of other disorders such as tuberculous.

Related Conditions & MeSH terms

• Cancer
• Mycobacterium
• Mycobacterium Infections
• Treatment Side Effects

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens	Picardie

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	variation of side effects number of non-tuberculous mycobacteria treatment between cancerous and non cancerous patient groups.	The main objective of this study is to determine the number of side effects of the treatment of non-tuberculous mycobacteria in patients with this infection with or without cancer at the CHU Picardie Amiens.	3 months