Cancer Clinical Trial
Official title:
An Observational Study of the Frequency of Oral Symptoms in Patients With Advanced Cancer
Observational study of prevalence of oral symptoms in patients with advanced cancer using a novel questionnaire ("Oral symptom assessment scale")
A novel questionnaire (the "Oral symptom assessment scale" / OSAS) has been developed to
assess a range of oral symptoms in patients with advanced cancer.
The OSAS consists of 20 symptoms, which were chosen following a review of the literature /
discussion with experts in the field. The OSAS was modelled on the Memorial Symptom
Assessment Scale (MSAS), and asks about the presence of the symptoms, the frequency of the
symptoms (i.e. "rarely"; "occasionally"; "frequently"; or "almost constantly"), the severity
of the symptoms (i.e. "slight"; "moderate"; "severe"; or "very severe"), and how much
distress they cause (i.e. "not at all"; "a little bit"; "somewhat"; "quite a bit"; or "very
much"). The questions relate to the last week.
Patients will be given the OSAS to complete, and also the short form of the MSAS (which asks
about the presence, and related distress, of 32 physical / psychological symptoms, including
a small number of oral symptoms). Demographic data, cancer diagnosis, and performance status
will also be collected. The study involves a single visit / assessment.
Descriptive statistics will be used to present the data, and hierarchical cluster analysis
will be used to identify oral symptom clusters. Kappa tests will be used to compare analogous
questions on the OSAS and short form MSAS (as part of the validation of the OSAS).
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