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The Role of SNP rs2910164 in Patients Treated With Immune Checkpoint Inhibitors

Cancer Clinical Trial

Official title:
A Single-Center, Prospective, Observational Trial to Analyze the Relationship Between Single Nucleotide Polymorphism rs2910164 and the Efficacy and Safety of Immune Checkpoint Inhibitor Therapy

Clinical Trial Summary

The objective of this study is to investigate whether the SNP rs2910164 in the pre-miR-146a gene is associated with outcome and toxicity of immune checkpoint inhibitor therapy.

Clinical Trial Description

The single nucleotide polymorphism (SNP) rs2910164 within the gene for microRNA-146a (miR-146a) reduces miR-146a expression. Previous studies of the investigators demonstrated that this SNP was associated with increased acute GvHD severity in patients undergoing allogeneic hematopoietic stem cell transplantation. In this prospective, observational study the investigators aim to analyze, whether SNP rs2910164 is associated with severity of immune-related adverse events of immune checkpoint inhibitor therapy. Moreover, association of rs2910164 with outcome parameters will be studied. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04038996
Study type Observational
Source University of Freiburg
Contact
Status Completed
Phase
Start date July 2016
Completion date February 2020
View Details
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