Cancer Clinical Trial
— PEACEOfficial title:
The PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study
| NCT number | NCT03004755 |
| Other study ID # | UCL/13/0165 |
| Secondary ID | |
| Status | Recruiting |
| Phase | |
| First received | |
| Last updated | |
| Start date | March 2014 |
| Est. completion date | November 2023 |
Historically, cancer research has been limited by sample acquisition in late stage disease, often restricted to single sites of disease with limited parallel clinical data collection in terms of prior therapy exposure. The PEACE study is intended to facilitate tissue donation from multiple tumour sites in the post-mortem setting and enable future research using samples collected at post-mortem within different disciplines related to cancer research.
| Status | Recruiting |
| Enrollment | 500 |
| Est. completion date | November 2023 |
| Est. primary completion date | November 2023 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Age 18 years or older - Confirmed diagnosis of any form of solid malignancy with metastatic disease (where the site of origin is known or unknown), with the exception of primary brain tumour in which there may not be evidence of metastatic disease - Oral and written informed consent from patient to enter the study and to undergo tumour harvesting after death or informed consent from a person in a qualifying relationship after the patient has died. Exclusion Criteria: - Medical or psychiatric condition that would preclude informed consent - History of intravenous drug abuse within the last 5 years - History of known high-risk infections (e.g. HIV/AIDS-positive, hepatitis B/C, tuberculosis and Creutzfeldt-Jacob disease). |
| Country | Name | City | State |
|---|---|---|---|
| United Kingdom | Heart of England NHS Foundation Trust | Birmingham | |
| United Kingdom | Cambridge University NHS Trust | Cambridge | |
| United Kingdom | Greater Glasgow Health Board | Glasgow | |
| United Kingdom | University Hospitals of Leicester NHS Trust | Leicester | |
| United Kingdom | Guy's and St Thomas NHS Foundation Trust | London | |
| United Kingdom | The Royal Marsden NHS Foundation Trust | London | |
| United Kingdom | University College London Hospitals NHS Foundation Trust | London | |
| United Kingdom | The Christie NHS Foundation Trust | Manchester | |
| United Kingdom | Oxford University Hospitals NHS Trust | Oxford |
| Lead Sponsor | Collaborator |
|---|---|
| University College, London | Cancer Research UK |
United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Perform 500 post mortems | 5 years |
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