Cancer Clinical Trial
— AgElOnOfficial title:
Fragmentation of Elastin as a Biological Marker of Frailty and Impact in Tumor Progression in Elderly Patients With Cancer
| NCT number | NCT02807129 |
| Other study ID # | PO12140 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | |
| Last updated | |
| Start date | January 2014 |
| Est. completion date | January 2024 |
| Verified date | October 2019 |
| Source | CHU de Reims |
| Contact | Rachid MAHMOUDI |
| Phone | 326784424 |
| rmahmoudi[@]chu-reims.fr | |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
The aim of the study is to evaluate frailty in patients aged ≥ 65 years with cancer. The
elderly population is very heterogeneous, it is necessary to evaluate these elderly patients
before treatment to assess the risk-benefit balance. To date, this assessment relies on
subjective clinical methods often not optimal, and slow to implement. An innovative method of
evaluation could be the determination of elastin peptides. Indeed, the rate of these
peptides, which are linked to serious conditions associated with age, rising inexorably with
age and dose could help determine more objectively the type of treatment to offer older
patients.
Expected results : This study will allow better identification of the group of frail elderly
through more relevant biological marker that clinical assessment, often subjective and not
available within a period compatible with the treatment of newly diagnosed cancer. This
biological assessment will also enable optimal management of elderly patients in particular
by allowing the geriatrician better efficiency.
| Status | Recruiting |
| Enrollment | 300 |
| Est. completion date | January 2024 |
| Est. primary completion date | January 2024 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 65 Years and older |
| Eligibility |
Inclusion Criteria: - 65 years or older - diagnosis of cancer - affiliation to a social security scheme - Signed informed consent for the study and for the collection of biological samples Exclusion Criteria: - Patient protected by law (guardianship, trusteeship) |
| Country | Name | City | State |
|---|---|---|---|
| France | Chu Reims | France | Reims |
| Lead Sponsor | Collaborator |
|---|---|
| CHU de Reims |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | elastin peptides quantification | up to 36 months |
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