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Next Generation Personalized Neuroblastoma Therapy — NEPENTHE  

Cancer Clinical Trial

Official title:
Next Generation Personalized Neuroblastoma Therapy (The NEPENTHE Trial)

Clinical Trial Summary

The purpose of this research study is to match genomic aberrations in tumor cells at time of relapse to rationally designed combinations of molecularly targeted agents. This study will be done in two parts: Part I: Tumor will be accessed at study entry via a biopsy and subjected to deep sequencing to identify protocol-specified biomarkers for therapy assignment. Part II: If the tumor contains a genetic change defined by the study as being actionable, and other criteria are met, participants will be assigned to therapy based upon the genetic changes identified in the tumor biopsy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02780128
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Terminated
Phase Phase 1
Start date July 2016
Completion date August 2022
View Details
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