Cancer Clinical Trial
Official title:
Mitochondrial Respiratory Function in Mammalian Skeletal Muscle: Metabolic Insights Into Cancer and Burn Cachexia Through Comparative Physiology of Humans and Marine Mammals
The purpose of this study is to determine whether skeletal muscle mitochondrial function is altered in patients with head and neck cancer compared to healthy controls.
20 men and women, 30-60 years, equally divided between patients diagnosed with advanced
(stages III or IV), persistent (recurrence within 6 months) or recurrent head and neck
squamous cell carcinoma (HNSCC) (n=10) and healthy age matched control subjects (n=10) will
be studied.
Muscle biopsies will be collected from cancer patients before and after a 4 week standard of
care (SOC) treatment. Muscle biopsies from healthy control subjects will be collected at
baseline only.
Lean body mass and fat mass will be determined by a DEXA scan before and after 4 week SOC
treatment (cancer patients) to document any change in body composition (cachexia), and at
baseline only in the age-matched healthy controls.
Blood will be collected from both cancer patients and healthy subjects to examine hormone
levels at the time of biopsy.
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