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Study of Theliatinib (HMPL-309) in Patients With Advanced Solid Tumor — HMPL-309  

Cancer Clinical Trial

Official title:
Open-label, Dose Escalation Phase I Study of Theliatinib (HMPL-309,Xiliertinib) in Patients With Advanced Solid Tumors

Clinical Trial Summary

A Phase I, open-label, multicenter dose-escalation study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of hmpl-309 in patients with advanced solid tumors

Clinical Trial Description

There are two stages to this study: a dose-escalation stage and a dose-expansion stage.

Dose-escalation stage: hmpl-309 administered orally once every day(QD) to patients with locally advanced or metastatic solid tumors for whom standard therapy either does not exist or has proven to be ineffective or intolerable. Dose-expansion stage: hmpl-309 administered orally 300mg once every day(QD) to patients which is only for patients with EGFR positive oesophageal carcinoma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02601274
Study type Interventional
Source Hutchison Medipharma Limited
Contact
Status Terminated
Phase Phase 1
Start date April 2015
Completion date December 2018
View Details
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