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Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors — AflacST1502  

Cancer Clinical Trial

Official title:
AflacST1502: A Phase II Study of Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors

Clinical Trial Summary

This study aims to determine the efficacy of daily sirolimus and celecoxib, with low dose etoposide alternating with cyclophosphamide for pediatric participants with relapsed or refractory tumors.

Clinical Trial Description

This study aims to learn if the combination of oral sirolimus once daily with celecoxib, and with oral etoposide alternating every 21 days with oral cyclophosphamide (metronomic chemotherapy) is effective in shrinking relapsed or refractory tumors in pediatric participants. In addition, this study seeks to learn the length of time this combination can keep the tumor from growing, learn more about the side effects of sirolimus when used in this combination, and to learn if the sirolimus is working by evaluating blood and tumor tissue. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02574728
Study type Interventional
Source Emory University
Contact Thomas Cash, MD
Email aflacdevtreferral@choa.org
Status Recruiting
Phase Phase 2
Start date June 2015
Completion date February 2025
View Details
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