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Identifying Mechanisms of Resistance to mTOR Inhibitors in Cancer

Cancer Clinical Trial

Official title:
Identifying Mechanisms of Resistance to mTOR Inhibitors in Cancer

Clinical Trial Summary

mTOR kinase is part of the mTORC1 complex that promotes cap-dependent protein translation, and part of the mTORC2 complex that activates AKT. Everolimus (Afinitor) is an allosteric inhibitor of mTOR that suppresses mTORC1 activity. Everolimus is FDA-approved for the treatment of ER+/HER2- breast cancer (in combination with exemestane), renal cell carcinoma, subependymal giant cell astrocytoma (SEGA), and neuroendocrine tumors of pancreatic origin (PNET), and is currently being tested in ongoing clinical studies in other indications. While everolimus-based therapies elicit anti-cancer effects, most cancers ultimately progress and exhibit everolimus resistance. This study will evaluate genetic mechanisms of resistance to everolimus.

Clinical Trial Description

n/a

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02306135
Study type Observational [Patient Registry]
Source Dartmouth-Hitchcock Medical Center
Contact
Status Terminated
Phase N/A
Start date March 2015
Completion date March 2016
View Details
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