Cancer Clinical Trial
— SPANCOfficial title:
The Natural History of Anal Human Papillomavirus Infection and Anal Cellular Abnormalities in Homosexual Men
Verified date | November 2019 |
Source | Kirby Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
SPANC stands for Study of the Prevention of Anal Cancer. There are more than 100 types of
human papillomavirus (HPV). Some HPV types cause genital warts and other types cause more
than 90% of anal cancer.
Gay men are over 20 times more likely than others to develop anal cancer.
SPANC is a study of anal (HPV) infection and related anal disease in gay men. The study will
provide important information to guide the possible future introduction of anal cancer
screening programs for gay men.
Status | Completed |
Enrollment | 617 |
Est. completion date | December 4, 2018 |
Est. primary completion date | May 4, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 35 Years and older |
Eligibility |
Inclusion Criteria: Male homosexual aged 35 years or above; HIV positive participants:
documented to be HIV positive; HIV negative participants: tested HIV negative at
recruitment; provision of informed, written consent. - Exclusion Criteria: participants unable to attend scheduled follow-up interviews or unwilling to undergo high resolution anoscopies (HRA); unable to understand English; having bleeding disorders or currently taking anti-coagulant medications; having previously received HRA; having ever been diagnosed with anal cancer. - |
Country | Name | City | State |
---|---|---|---|
Australia | Applied Medical Research (AMR CRP), St. Vincent's Hospital | Sydney | New South Wales |
Australia | RPA Sexual Health, Royal Prince Alfred Hospital, Camperdown | Sydney | New South Wales |
Lead Sponsor | Collaborator |
---|---|
Kirby Institute |
Australia,
Machalek DA, Grulich AE, Hillman RJ, Jin F, Templeton DJ, Tabrizi SN, Garland SM, Prestage G, McCaffery K, Howard K, Tong W, Fairley CK, Roberts J, Farnsworth A, Poynten IM; SPANC Study Team. The Study of the Prevention of Anal Cancer (SPANC): design and methods of a three-year prospective cohort study. BMC Public Health. 2013 Oct 9;13:946. doi: 10.1186/1471-2458-13-946. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | A natural history study to inform the potential usefulness of a cytology/HPV/HRA based screening program | Aims to determine the prevalence, incidence and risk factors for type-specific HPV (37 types) | 3 year cohort study | |
Secondary | Prevalence, incidence and risk factors for LSIL and HSIL | To determine if HPV is associated with LSIL and HSIL | 3 year cohort study |
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