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Tissue Study of Bv8/PK-2 Inhibition in Human Cancer

Cancer Clinical Trial

Official title:
Study of Human Primary Cancer Tissue Implanted in Mice Lacking Bv8/PH-2 in Their Bone Marrow-derived Cells

Clinical Trial Summary

Study hypothesis is that inhibition of Bv8 production in bone marrow cells of a mice wil reduce the rate of growth of a primary human tumor implanted in the mice. we will take mice and transform their bone marrow cells into non-Bv8 producing cells. than we will implant primary human tumor tissue (taken from surgical specimens after informed consent)in those mice and follow-up on the mice.

Clinical Trial Description

1-10 grams of human cancer tissue will be taken from surgical specimen without interference to the pathological data gathering process. those tissues will be implanted in nude mice that will either be treated with anti-Bv8 antibodies or will be transplanted with bone marrow in which Bv8 expression is silenced. ;

Study Design

N/A

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01656824
Study type Observational
Source Rambam Health Care Campus
Contact Erez Hasnis, MD; PhD
Phone 972-50-2061911
Email e_hasnis@rambam.health.gov.il
Status Recruiting
Phase N/A
Start date August 2012
Completion date October 2014
View Details
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