Cancer Clinical Trial
Official title:
Long-term Follow-up of Childhood Cancer Survivors in the Rhône-Alpes and Auvergne Regions of France
Childhood cancers are rare, and today 75% of patients survive them. An estimated one out of
850 French persons has survived childhood cancer. However, the complications of
chemotherapy, radiotherapy or surgery can lead to a higher risk of secondary mortality,
which the literature estimates is at 14%. Regular care has a positive impact on the quality
of life and health of adults who survived cancer during their childhoods. It aims to detect
the potential long-lasting effects of cancer and to provide therapeutic education and
psychological care. Thanks to cancer registries, several countries (USA, Canada, UK,
Germany, the Netherlands) have developed long-term care structures which function with
specially trained adult medicine practitioners. There are only two structures in France: the
Long-Term Oncology/Hematology Follow-Up Clinic, headed by Dr François Pein, in Nantes
(France), and the LEA program for the follow-up of children treated for leukemia in the
PACA-Corse and Lorraine regions of France, which began in 2003 and has since been extended
to other centers.
The Rhône-Alpes and Auvergne regions have had childhood cancer registries since 1987; they
compile about 200 new cases a year. The Rhône-Alpes registry has conducted a preliminary
trial on children (0-15 years old) diagnosed with cancer between 1987 and 1992. They
analyzed the correlation between patients' quality of life and the long-term medical effect
of cancer and treatment, both recorded in patients' medical files and declared by patients.
These young adults who survived pediatric cancer appear to suffer from and declare many
complications, although this does not impact their global quality of life much. There is a
negative correlation between the number of complications (observed or declared) and the
global quality of life score, but only three types of complications play a significant role
(motor function complications, auditory complications, and alopecia.) In addition, there is
a significant mismatch between patients's perceived health (what they say they experience),
and the information contained in their medical files. These young adults expressed the need
for their impressions to be better taken into account by health care professionals. This
study does not assess patients' psychopathological characteristics.
Results will help identify long-term complications, respond to patients' expectations, and evaluate the feasibility of conducting such a follow-up in all patients. They should guide the choice of the most appropriate tools for care, help assess needs in terms of collaboration with adult care staff, and identify potential partners. ;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05346796 -
Survivorship Plan HEalth REcord (SPHERE) Implementation Trial
|
N/A | |
| Recruiting |
NCT05094804 -
A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents
|
Phase 1/Phase 2 | |
| Completed |
NCT04867850 -
Effect of Behavioral Nudges on Serious Illness Conversation Documentation
|
N/A | |
| Enrolling by invitation |
NCT04086251 -
Remote Electronic Patient Monitoring in Oncology Patients
|
N/A | |
| Completed |
NCT01285037 -
A Study of LY2801653 in Advanced Cancer
|
Phase 1 | |
| Completed |
NCT00680992 -
Study of Denosumab in Subjects With Giant Cell Tumor of Bone
|
Phase 2 | |
| Completed |
NCT00062842 -
Study of Irinotecan on a Weekly Schedule in Children
|
Phase 1 | |
| Active, not recruiting |
NCT04548063 -
Consent Forms in Cancer Research: Examining the Effect of Length on Readability
|
N/A | |
| Completed |
NCT04337203 -
Shared Healthcare Actions and Reflections Electronic Systems in Survivorship
|
N/A | |
| Recruiting |
NCT04349293 -
Ex-vivo Evaluation of the Reactivity of the Immune Infiltrate of Cancers to Treatments With Monoclonal Antibodies Targeting the Immunomodulatory Pathways
|
N/A | |
| Terminated |
NCT02866851 -
Feasibility Study of Monitoring by Web-application on Cytopenia Related to Chemotherapy
|
N/A | |
| Active, not recruiting |
NCT05304988 -
Development and Validation of the EFT for Adolescents With Cancer
|
||
| Completed |
NCT04448041 -
CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
|
||
| Completed |
NCT00340522 -
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
|
||
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Active, not recruiting |
NCT03844048 -
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
|
Phase 3 | |
| Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
| Completed |
NCT03109041 -
Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source
|
Phase 1 | |
| Terminated |
NCT01441115 -
ECI301 and Radiation for Advanced or Metastatic Cancer
|
Phase 1 | |
| Recruiting |
NCT06206785 -
Resting Energy Expenditure in Palliative Cancer Patients
|