Cancer Clinical Trial
Official title:
Fungemia Survey in Cancer Patients
RATIONALE: Gathering information about how often fungal infections of the blood occur in
patients with cancer or in patients who have undergone stem cell transplant may help doctors
learn more about the disease.
PURPOSE: This natural history study is collecting information about fungal infections of the
blood over time from patients with cancer or from patients who have undergone a stem cell
transplant.
OBJECTIVES:
- Determine the incidence of fungemia in relation to the number of admissions to the
hospital in patients with solid tumor or hematologic malignancy or in patients who have
undergone hematopoietic stem cell transplantation.
- Determine the fungal species distribution, prognostic factors for outcome, and crude and
attributable mortality in patients also diagnosed with fungemia.
OUTLINE: This is a multicenter, nonrandomized, prospective study.
- Group A (no documented fungemia at study entry): Data regarding the number of patients
with cancer or who have undergone hematopoietic stem cell transplantation, including
those who develop documented fungemia, who are admitted to the hospital is collected for
2 years.
- Group B (documented fungemia at study entry): Fungal strains isolated from the initial
positive blood culture are collected and undergo examination, including confirmation of
species identification, susceptibility testing, and/or minimum inhibitory concentration
determination. Data, including antifungal treatment, clinical and microbiological
response to antifungal treatment (at 2, 4, and 12 weeks after diagnosis), and survival
status, is collected for each documented fungemia episode* for up to 12 weeks after
diagnosis of fungemia.
NOTE: *That occurs within a 2-year period.
PROJECTED ACCRUAL: A total of 300 patients will be accrued for this study.
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