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NCT00166647 Clinical Trial

Thiopurine Methyltransferase Polymorphisms Evaluation

Cancer Clinical Trial

Official title:
Evaluation of Thiopurine Methyltransferase Polymorphisms in the Hispanic Population

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT00166647
Other study ID # PPRU-10728
Secondary ID
Status Withdrawn
Phase Phase 4
First received September 9, 2005
Last updated January 10, 2013
Start date February 2004

Study information
Verified date January 2013
Source Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

The purpose of the study is to determine the frequency of allelic variants in TPMT in the Hispanic population and to compare the frequency in the Hispanic population with the Caucasian Population.

Description:

Relatively few studies have been performed evaluating the variant allele frequencies in Spanish populations. To date, no studies evaluating the TPMT variant allele frequency in the Hispanic population have been reported. Hispanics are a growing part of the patient population treated in the United States. Characterization of the proportion of patients with variant genotypes in this population is important since Hispanic children represent a significant proportion of children being treated with thiopurines.

A single 3 cc heparinized blood sample will be obtained for TPMT genotyping. The sample will be obtained either simultaneously with a clinical sample, at the time of an otherwise medically indicated intravenous catheter placement or scavenged from excess blood remaining following clinical laboratory testing.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A to 18 Years
Eligibility Inclusion Criteria:

- All Hispanic children and adolescents diagnosed and treated at Texas Children's Cancer Center within the last 5 years for malignant diseases/cancer and non-malignant hematological disorders that necessitate chemotherapy

- All Hispanic children and adolescents who will be treated at Texas Children's Center for malignant diseases/cancer and non-malignant hematological disorders that will necessitate chemotherapy.

Exclusion Criteria:

- Any child or adolescent registering at Texas Children's Cancer Center and not requiring any form of therapy.

Study Design

N/A

Related Conditions & MeSH terms

Intervention

Procedure:
• Blood Sampling

Locations
Country Name City State
United States Baylor College of Medicine, Texas Children's Hospital Houston Texas

Sponsors (1)
Lead Sponsor Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Country where clinical trial is conducted

United States, 

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