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NCT00023140 Clinical Trial

Collaborative Study of 1,3 Butadiene Biomarkers

Cancer Clinical Trial

Official title:
Collaborative Study of 1,3 Butadiene Biomarkers

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00023140
Other study ID # 9401-CP-001
Secondary ID
Status Completed
Phase N/A
First received August 22, 2001
Last updated April 13, 2015
Start date July 1999
Est. completion date June 2002

Study information
Verified date April 2015
Source National Institute of Environmental Health Sciences (NIEHS)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.

Recruitment information / eligibility
Status Completed
Enrollment 80
Est. completion date June 2002
Est. primary completion date May 2002
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 19 Years to 65 Years
Eligibility Healthy adults without metabolic disorders

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan National Chung Kung University Tainan
United States Harvard School of Public Health Boston Massachusetts

Sponsors (1)
Lead Sponsor Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Countries where clinical trial is conducted

United States,  Taiwan, 

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