Cancer Clinical Trial
Official title:
Stem Cell Augmented, Elutriated Grafts for Allogeneic Bone Marrow Transplantation
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were
destroyed by chemotherapy or radiation therapy used to kill tumor cells. Sometimes the
transplanted cells can make an immune response against the body's normal tissues. Stem cells
that have been treated in the laboratory to remove lymphocytes may prevent this from
happening.
PURPOSE: Clinical trial to prevent graft-versus-host disease in patients undergoing bone
marrow transplantation.
OBJECTIVES:
- Determine whether stem cell augmented, elutriated grafts prevent graft versus host
disease in patients undergoing allogeneic bone marrow transplantation.
OUTLINE: Patients receive elutriated CD34+ augmented donor bone marrow on day 0.
Bone marrow samples are obtained before day 100, around 6 months, and 1 year after
transplant.
PROJECTED ACCRUAL: Not specified
;
Primary Purpose: Supportive Care
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