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Clinical Trial Summary

The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.


Clinical Trial Description

The CAFÉ Study aims to determine the degree to which loss-of-function variants in the CTNNA1 gene are associated with hereditary cancers, including gastric cancer, breast cancer, as well as other cancers that may be associated with this gene. By obtaining personal and family history information from individuals who carry a CTNNA1 loss-of-function variant and their family members, this study will aim to better define CTNNA1 associated cancer risks and determine whether there is a genotype/phenotype correlation for CTNNA1 loss-of-function variants. This information will be important for the future cancer risk management of individuals who carry a CTNNA1 loss-of-function variant. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05126290
Study type Observational [Patient Registry]
Source Abramson Cancer Center at Penn Medicine
Contact Bryson W Katona, MD, PhD
Phone 215-349-8222
Email cafestudy@pennmedicine.upenn.edu
Status Recruiting
Phase
Start date March 16, 2021
Completion date January 1, 2026

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