Cancer, Breast Clinical Trial
Official title:
K-ACCELERATE: A Multi-center Prospective Trial to Evaluate Clinical Utility of Multi Cancer Early Detection Test as a Triage Test for Symptomatic Participants
To evaluate the diagnostic performance of blood-based SPOT-MAS test in symptomatic individuals, the investigators sought to launch a prospective multicenter study, named K-ACCELERATE. The study aims to recruit 1,000 participants who develop symptoms and signs specific to the top five common cancer types including breast, colorectal, gastric, liver and lung cancer. Primary objective: Evaluate the performance of the SPOT-MAS test in detecting cancer in symptomatic populations. Secondary objectives: Evaluate the feasibility of incorporating SPOT-MAS as a triage test into primary care to increase the detection rates of malignant cancer while minimizing unnecessary referrals to invasive procedures.
Participants are recruited and referred to one of the five diagnosis pathways according to the participants' symptoms and signs listed. Before undertaking imaging tests, 10 ml of blood is collected in Streck tube for SPOT-MAS test. Participants undertake low-resolution imaging (LRI) tests matching with participants' referral diagnosis pathway. Imaging test results are returned within the same day. If participants get negative results from both SPOT-MAS and LRI, participants will receive treatment for the symptoms based on the standard treatment scheme at hospitals and be followed up for 12 months to confirm their cancer-free status. - If participants get a positive result from either SPOT-MAS or LRI, participants will be referred to high-resolution imaging tests (HRI) or tissue biopsy to confirm the presence of tumor. For those with positive results confirming invasive tumors by HRI or tissue biopsy, patients will undergo treatment. The investigators do not provide financial support for their treatment. For those with no invasive lesions but having positive SPOT-MAS results, participants will be advised to re-take the SPOT-MAS test after 6 months. If the 2nd SPOT-MAS test results return positive, participants will be advised to perform whole body CT scan. If participants' scanning results return positive, participants will undergo tissue biopsy and treatment. If the 2nd SPOT-MAS or whole body CT scan is negative, participants will be followed-up for an additional 6 months by surveying to confirm the cancer-free status. The enrolment is anticipated to last for approximately 6 months ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04416087 -
Exercise and Tumor Blood Flow in Breast Cancer Patients
|
N/A | |
Active, not recruiting |
NCT04726319 -
Family History App in Personalized Medicine
|
N/A | |
Recruiting |
NCT05800834 -
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
|
Phase 2 | |
Completed |
NCT04692168 -
Influence of Chemotherapy on Postural Control in Women With Cancer
|
||
Recruiting |
NCT06152419 -
Patient Education Videos to Improve Patients' Experience During Radiotherapy Treatment: a National Project
|
N/A | |
Recruiting |
NCT03709134 -
Genomic Markers for Measuring Breast Cancer Response to Neoadjuvant Chemotherapy
|
||
Completed |
NCT03282214 -
A Self-Management Energy Conservation Program for Cancer-Related Fatigue
|
Phase 2 | |
Recruiting |
NCT06275321 -
Physical Exercise Benefits for Cancer Patients
|
N/A | |
Recruiting |
NCT05711030 -
Thoracic Paravertebral Block Anesthesia for Breast Cancer Surgery
|
N/A | |
Suspended |
NCT03271853 -
Thermalogical Analysis of a Cohort of Women and Men Undergoing Mammographic Analysis.
|
N/A | |
Active, not recruiting |
NCT03144947 -
Biomarker Study of Immune-mediated Mechanism of Action of Neoadjuvant Trastuzumab in HER2+ Breast Cancer Patients
|
Phase 2 | |
Completed |
NCT02996201 -
Electronic Patient Reporting of Side Effects to Chemotherapy: A Cluster Randomized Controlled Trial
|
N/A | |
Recruiting |
NCT05573022 -
Impact of a Patient Decision Aid Intervention
|
N/A | |
Completed |
NCT05161312 -
A Guided Online Intervention to Improve Quality of Life in Breast Cancer Patients - a Randomised Clinical Trial
|
N/A | |
Completed |
NCT04836221 -
Comorbidities And Reducing inEquitieS
|
N/A | |
Recruiting |
NCT06345534 -
FAST-FORWARD vs HAI5
|
N/A | |
Enrolling by invitation |
NCT06409221 -
VISION: Triple Negative Breast Cancer Sample and Clinical Data Acquisition Study
|
||
Not yet recruiting |
NCT03910283 -
Leveraging Mindsets to Improve Health & Wellbeing in Patients With Cancer
|
N/A | |
Completed |
NCT03612934 -
The Impact of SPC on Advanced Breast Cancer Patients
|
||
Recruiting |
NCT03301493 -
Genomic Testing and Resulting Medical Decisions
|