Cancer, Breast Clinical Trial
Official title:
Exercise and Tumor Blood Flow in Breast Cancer Patients (Exetumor 2)
This research aims at investigating tumor blood flow response to acute exercise in human cancer patients. It is hypothesized and expected that acute exercise increases tumor blood flow, which could plausibly increase the efficacy of cancer treatment.
Physical activity has been applied as an adjunctive therapy in the secondary prevention of
many cancers, but very little is currently known clinically and mechanistically about the
effects of physical activity and exercise on tumor itself. Based on recent evidence from
pre-clinical studies, it is plausible to expect that changes in tumor blood flow and its
heterogeneity, oxygenation, and metabolism due to exercise would increase the delivery of
chemotherapy and other cancer drugs into the tumor increasing the efficacy of cancer
treatment.
Twenty (20) newly diagnosed Breast cancer patients will be recruited to investigate whether
these pre-clinical findings can be extended to humans to serve as an evidence-based
proof-of-concept for the possible inclusion of exercise in the treatment of cancer during
chemotherapy. To study the effect of acute physical exercise on tumor blood flow and its
heterogeneity, supine bicycle exercise in a positron emission tomography (PET) scanner will
be used to exercise Breast cancer patients. These experiments are additional measurements to
their normal treatments, and no new interventional approaches will be conducted in this
study.
The study consists of one fitness test assessment, and tumor blood flow measurements with PET
at rest and during supine cycling exercise.
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