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Bypass Complications clinical trials

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NCT ID: NCT02641301 Active, not recruiting - Clinical trials for Bypass Complications

Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects

OBEMO2
Start date: December 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether sustained release morphine pharmacokinetics parameters in patients undergone roux-en-y gastric bypass (RYGB) differ from subjects who did not. Our hypothesis is that exposure is comparable. Indeed, in the Study OBEMO (Determinants of Oral Morphine Answer Among Obese Patients Before and After Gastric Bypass; NCT00943969) the investigators observed changes in pharmacokinetics parameters for immediate release morphine, probably due to an earlier absorption of the morphine, in agreement with the expected clinical effect of this formulation.

NCT ID: NCT02601092 Recruiting - Obesity Clinical Trials

Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Mini Gastric Bypass

MGB
Start date: October 2016
Phase: N/A
Study type: Interventional

Several retrospective studies have shown same efficiency in regard to weight loss, with a lower rate of complications for the laparoscopic mini gastric bypass (LMGB) compared to Roux-en-Y gastric bypass (LRYGB). The aim of this double-blinded randomized controlled trial is to compare the two procedures in respect of excess weight loss, complications, operation time, length of stay and the metabolic impact on the hormonal brain-gut-axis.

NCT ID: NCT02328846 Withdrawn - Clinical trials for Bypass Complications

Transcutaneous-Arterial Carbon Dioxide and Microcirculatory Dysfunction

Start date: January 2018
Phase:
Study type: Observational

Evaluation of the microcirculation is currently limited. Continual assessment of the tissue carbon dioxide-arterial carbon dioxide (PtC02-aCO2) offers a new, novel and noninvasive method of determining the state of the microcirculation. The investigators will apply two non-invasive devices, the Braedius sidesteam darkfield microscopy (SDF) microscopy device to the sublingual circulation and the transcutaneous PtC02 probe to the forehead in subjects undergoing cardiac surgery with cardiopulmonary bypass. The PtC02-aCO2 gradient will be determined and correlated with the videomicroscopic images of the sublingual microcirculation. Thereafter the incidence of postoperative organ failure and acute kidney injury will be determined and correlated with PtC02-arterial CO2 gradient and videomicroscopic images. Data will be analyzed by standard descriptive statistical methods.

NCT ID: NCT02295150 Recruiting - Morbid Obesity Clinical Trials

Prophylaxis of Venous Thromboembolism After Bariatric Surgery

Start date: March 2013
Phase: Phase 4
Study type: Interventional

This study is a prospective evaluation of the relationship between lean body weight and anti-Xa activity and 5700 International Units (IU) nadroparin 4 hours after subcutaneous administration in morbidly obese patients after bariatric surgery.

NCT ID: NCT01896063 Completed - Clinical trials for Bypass Complications

Sedative and Hypnotic Effects Induced by EA

Start date: September 2011
Phase: Phase 1
Study type: Interventional

Insomnia is a common clinical disease.The serious patients could not sleep all night, often accompanied by headache, dizziness, forgetfulness and so on. All of these increase the mental burden of insomnia patients and seriously affected the normal work and quality of life of patients. Modern medical treatment to treat insomnia is using sedative and hypnotic drugs, mainly benzodiazepine, zopiclone. But long-term use of these drugs can induce the adverse reactions, including resistance, dependence and addiction. Many articles indicate that electroacupuncture can effectively improve insomnia, play the role of sedative and hypnotic effect and avoid many adverse reactions and side effects. Then there are no more objective indicators to affirm that which part of brain takes place the appropriate changes when electroacupuncture induces the sedative effect. So we designed this experiment.

NCT ID: NCT01698853 Not yet recruiting - Clinical trials for Bypass Complications

Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy

Start date: October 2012
Phase: N/A
Study type: Observational

Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion. Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied. The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated.

NCT ID: NCT01450475 Completed - Ischemia Clinical Trials

Study of Remote Ischemic Postconditioning

Start date: August 2011
Phase: Phase 1
Study type: Interventional

Cardiac surgery is associated with cardiac and cerebral injury because of ischemia/reperfusion in approximately one third of cases. Ischemic preconditioning (IPC), have been shown to reduce the extent of myocardial infarction (MI). As another ischemic conditioning, remote ischemic postconditioning, limits MI size in animal models. The purpose of this study is to evaluate the cardiac and cerebral protective effect of remote ischemic postconditioning in children undergoing cardiac surgery, as a single-center, randomized controlled trial.

NCT ID: NCT01379638 Completed - Clinical trials for Bypass Complications

Best Cardiac Output During Cardiopulmonary Bypass

Start date: December 2008
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.