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NCT ID: NCT06366776 Not yet recruiting - Clinical trials for Vitamin D Deficiency

Emulated Study of Vitamin D Correction vs Non-Correction

Start date: April 2024
Phase:
Study type: Observational

- This is a single-site retrospective electronic chart review of Cooper Health System Inpatients and Outpatients from 2008 through 2023 aged eighteen years or older. This review is designed as an emulation of a randomized clinical trial with a nonrandomized database. - The primary objectives are to compare healthcare costs and healthcare utilization between subjects who have corrected low vitamin D levels and those without corrected low vitamin D levels.

NCT ID: NCT06366789 Not yet recruiting - Clinical trials for AML With Gene Mutations

Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated Relapsed or Refractory Acute Myeloid Leukemia

Start date: April 2024
Phase: Phase 1
Study type: Interventional

This is a clinical study aiming to assess pharmacokinetics, pharmacodynamics and preliminary efficacy of ZE46-0134 in patients with FLT3 mutated Relapsed or Refractory Acute Myeloid Leukemia

NCT ID: NCT06367114 Not yet recruiting - Clinical trials for Relapsed or Refractory Acute Lymphoblastic Leukemia

Clinical Trial of ssCART-19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)

Start date: April 2024
Phase: Phase 2
Study type: Interventional

This study is a Phase II, single-arm, open-label, non-randomized, dose-escalation clinical trial to evaluate the efficacy and safety of ssCART-19 Cell Injection in the treatment of patients with CD19 positive Relapsed or Refractory acute lymphoblastic leukemia, including central nervous system infiltration.

NCT ID: NCT06367660 Not yet recruiting - Visceral Pain Clinical Trials

Comparison Between Hyperbaric Bupivacaine With Fentanyl vs. Hyperbaric Bupivacaine With Dexmedetomidine in Reducing Visceral Pain During Cesarean Delivery Under Spinal Anaesthesia

Start date: April 2024
Phase: Phase 4
Study type: Interventional

In patients undergoing elective LSCS under subarachnoid block, group BF will receive 0.5% hyperbaric bupivacaine 10mg (2ml) with fentanyl 10 mcg (0.2ml) with total of 2.2 ml and group BD will receive 0.5% hyperbaric bupivacaine 10 mg with Dexmedetomidine 5mcg (0.2ml) total volume 2.2ml. Assessment of intraoperative visceral pain will be done by self-reporting of patients, who are previously educated, as poorly localized discomfort or dragging, pulling heaviness or unpleasant feeling or pain with or without nausea and will be categorized according to preformed scale

NCT ID: NCT06368167 Not yet recruiting - Follicular Lymphoma Clinical Trials

A Phase II Study of SHR2554 in Patients With Relapsed or Refractory Follicular Lymphoma

Start date: April 2024
Phase: Phase 2
Study type: Interventional

The study is being conducted to evaluate the efficacy and safety of SHR2554 in Patients with Relapsed or Refractory Follicular Lymphoma

NCT ID: NCT06368219 Not yet recruiting - Procedural Sedation Clinical Trials

Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting

Start date: April 2024
Phase: Early Phase 1
Study type: Interventional

This single blinded parallel randomized clinical trial will be conducted on 50 patients presented to Emergency Department of Alexandria Main University Hospital who are indicated for procedural sedation. All patients included in the study will be allocated randomly using computer software with concealment of randomization in to two groups: - Group A: 25 patients will receive ketamine (0.5 mg/kg) plus midazolam (0.05 mg/kg) - Group B: 25 patients will receive ketamine (0.5 mg/kg) plus propofol (0.5 mg/kg) Additional ketamine (0.25 mg/kg) will be administered in case of inadequate sedation in both groups. the two groups will be compared as regard incidence of complications World Society of Intravenous Anesthesia (SIVA) international sedation task force to standardize reporting adverse events

NCT ID: NCT06368297 Not yet recruiting - Clinical trials for Overweight and Obesity

The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults

Start date: April 2024
Phase: N/A
Study type: Interventional

This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to compare the effect of a ketogenic diet versus ketone ester supplementation on motor cortex plasticity, resting brain function and structure, and metabolic and neuroendocrine responses.

NCT ID: NCT06368596 Not yet recruiting - Endometriosis Clinical Trials

ENDS (ENDometriosis & FuSobacterium) Unveiling the Contribution of Fusobacterium Infection to the Development of Endometriosis

ENDS
Start date: April 2024
Phase: N/A
Study type: Interventional

This will be a clinical interventional longitudinal study, without pharmacological intervention/device evaluation. A control group would however be recruited for secondary objective 1 and 2. The study is classified as interventional, as Fusobacterium detection is not part of the routine management of these patients; from the patients' point of view, participation in the study will involve the execution of additional vaginal and cervical swabs as additional procedure, while the endometrial biopsy will not represent an additional examination, as the study will include only patients for whom this examination is expected as per normal clinical practice.

NCT ID: NCT06368609 Not yet recruiting - Clinical trials for Strongyloides Stercoralis Infection

Preliminary Evaluation of Two Rapid Diagnostic Test Prototypes for Strongyloides Stercoralis Infection

PROTOSS
Start date: April 2024
Phase: N/A
Study type: Interventional

Single center, no profit experimental study on sera available in the Tropica Biobank.

NCT ID: NCT06368622 Not yet recruiting - Clinical trials for Intracranial Aneurysm

Evolve China PMCF Study

Start date: April 2024
Phase:
Study type: Observational

A prospective, multi-center, single-arm, open-label, observational post-market real-world registry. The expected duration of the study is 8 years (including up to 5-years' follow-up). Each subject will be followed in accordance with the standard of care (SOC) at each participating hospital.